therapurebio-innovations
therapurebio-innovations
therapurebio-innovations

Advancing treatment of disease with innovative protein therapeutics and technologies

Making drugs work better through protein conjugation

Our protein drug conjugation platform technology takes advantage of hemoglobin, a natural protein the body uses to transport oxygen to tissues. Linking drugs to hemoglobin can provide two distinct advantages:

  • Improved delivery and transport of drugs to specific sites of action
  • Increased plasma stability of the platform limits the release of active drug into the circulation

Together these features may allow for increased levels of potent drugs to be delivered directly to target tissues with reduced systemic bioactivity, thereby limiting the potential for unwanted side effects through drug contact with non-target tissue.

Our leading protein drug conjugation technology, which is similar to antibody drug conjugation (ADC), covalently links drugs to hemoglobin (Hb). This technology takes advantage of the liver’s high-capacity recycling and replenishment system for Hb. The liver processes up to 6 grams of Hb daily, making Hb-conjugated drugs ideal for targeted delivery of drugs to the liver.

We use our hemoglobin conjugation technology in two of our pipeline products:

  • TBI 302 is a conjugate of Hb and floxuridine (FUdR), a potent chemotherapy drug used for the treatment of a variety of cancers including liver cancer
  • TBI 301 is an Hb-conjugate of ribavirin (RBV), one of the standard drugs for the treatment of chronic hepatitis C virus infection

For more information about the science behind our protein drug conjugation technology, please refer to an article by Brookes and colleagues.

innovation

To learn more about our areas of research, platform technologies and pipeline products, or to explore opportunities to partner and/or collaborate with us to improve existing therapeutics, please contact us at innovations@therapurebio.com.

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Copyright ©2013 Therapure Biopharma Inc.

Therapure Biomanufacturing & Therapure Innovations are divisions of Therapure Biopharma Inc.

EVENTS

October 21st-23rd, 2014

Bioprocess International
Boston, MA, USA

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NEWS

June 11, 2013

Therapure Biopharma Inc. Awarded US Government Contract for Development of Anti-Nerve Gas Agent

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AWARDS

September 11, 2013

2013 CMO Leadership Award

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