Advantages

Eliminate issues with capturing plasma proteins associated with using conventional chromatography

Conventional packed bed chromatography is associated with practical issues that limit its throughput capacity and efficiency, ultimately lowering its cost-effectiveness for capturing plasma proteins. PlasmaCap EBATM incorporates innovative features into an expanded bed adsorption (EBA) chromatography technology to eliminate some issues associated with plasma protein capture using conventional packed bed chromatography.

The table below summarizes how PlasmaCap EBA overcomes issues with packed bed chromatography.

Issue Plasma Protein Capture with
Packed Bed
PlasmaCap EBA
Advantage
PlasmaCap EBA
Benefits

Low material throughput

Large pressure drop along column limits flow rate of material

Minimal pressure drop along column; material throughput limited only by rate of ligand-protein interaction

  • Increased throughput capacity
  • Faster cycles
  • Smaller manufacturing footprint requirements

Column packing

Requires validated packing skids which are cumbersome and require extra steps and space

No column packing

  • Fewer steps
  • Lower operating costs
  • Smaller manufacturing footprint requirements

Asymmetrical column packing

Requires repacking

No column packing

  • Fewer steps
  • Lower operating costs

Maintaining a high Height Equivalent to Theoretical Plate (HETP)

Requires repacking

No column packing

  • Fewer steps
  • Lower operating costs

Particulate / precipitate in process stream

Requires pre-filter; adsorbent clogging may still occur requiring repacking

No clogging occurs; particulates / precipitates pass through void space of expanded adsorbent bed

  • Fewer steps
  • Lower operating costs
  • Flexible choice of starting material

Fouling of adsorbent bed

Requires repacking

Resistant to fouling; clean in place with 1 M sodium hydroxide at high temperatures easily removes foulants

  • Fewer steps
  • Lower operating costs

Air bubbles in process stream

Requires bubble trap; bubbles may still pose a concern, disturbing chromatography operations

Accommodates bubbles without adversely affecting chromatography operations

  • Fewer steps
  • Lower operating costs
advantage

To learn more about how plasma protein manufacturers and other biomanufacturing organizations can take advantage of PlasmaCap EBA, please contact us.

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